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John and Lonnie

Episode number: 1

Overview: The brothers shock Dr. Now with their staggering collective weight loss.

Holly and Lashanta

Episode number: 2

Overview: Holly has come a long way in her weight loss journey, but now she's trying to balance a wedding and skin surgery. Lashanta struggles to lose any weight at all. When a car drives through a wall in her living room, her weight loss is curtailed even more.

Robin and Garrett

Episode number: 3

Overview: Robin and Garrett started their weight-loss journeys together as aunt and nephew. Now almost four years later, they continue to support each other to reach their target weights by shedding pounds and having skin removal surgeries.

Vianey and Allen

Episode number: 4

Overview: Vianey and Allen have been on a weight loss journey together. But after Allen's surgery is a success and Vianey's is not, the couple struggles to get back on the same page to save their lives.

Octavia and Aaron

Episode number: 5

Overview: After regaining her mobility, Octavia is determined never to be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track. Aaron is laid low by the death of his father, but true love saves him.

Lacey and Mercedes

Episode number: 6

Overview: Even after surgery, Lacey's weight loss moves at a glacial pace. She says she wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight. Meanwhile, abandoned in Houston by her cousin, Mercedes and her kids face destitution.