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Chapter 1: LSD

Episode number: 1

Overview: From its 1943 origins to today's microdosing trend, LSD has been expanding minds and changing lives with the help of counterculture gurus — and the CIA.

Chapter 2: Psilocybin

Episode number: 2

Overview: Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring their intense effects.

Chapter 3: MDMA

Episode number: 3

Overview: Championed by both therapists and ravers, ecstasy stands out as the first psychedelic likely to become legalized, thanks to passionate advocates.

Chapter 4: Mescaline

Episode number: 4

Overview: Mescaline, the psychoactive molecule in San Pedro and peyote cacti, a sacred medicine that Native Americans have had to fight for the right to use.