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Mandy Moore
Episode number: 1
Keira Knightley
Episode number: 2
Elle MacPherson
Episode number: 3
Wynonna Judd
Episode number: 4
Amanda Bynes
Episode number: 5
Lee Ann Womack
Episode number: 6
The Sopranos' Steve Schirripa
Episode number: 7
Jon Favreau
Episode number: 8
Rob and Amber from Survivor
Episode number: 9
Carla Gugino & Elisabeth Hasselbeck
Episode number: 10
Tom Arnold
Episode number: 11
Shania Twain
Episode number: 12
Niecy Nash
Episode number: 13
Andie MacDowell
Episode number: 14
Sarah Jessica Parker
Episode number: 15
Rachael Ray
Episode number: 16
Selma Blair
Episode number: 17
Matthew Modine
Episode number: 18
Rent's Anthony Rapp
Episode number: 19
Gastineau Girls
Episode number: 20
Isaac Makes You Fashion Fabulous
Episode number: 21
Madonna
Episode number: 22
Finola Hughes
Episode number: 23
Isaac and the City
Episode number: 24
Sela Ward
Episode number: 25
Overview: Sela Ward; Jaime Pressly. Also: a segment on ice-cream recipes.
Andrew Firestone
Episode number: 26
Rob Morrow
Episode number: 27
Cynthia Nixon
Episode number: 28
Nia Long
Episode number: 29
Bo Bice & Shannon Elizabeth
Episode number: 30
Margaret Cho
Episode number: 31
Michael Moloney
Episode number: 32
Kimora Lee Simmons
Episode number: 33
Isaac's Glamour Girls
Episode number: 34
Iman
Episode number: 35
Isaac Strikes Again
Episode number: 36
Rosie Perez
Episode number: 37
Lisa Loeb
Episode number: 38
S. Epatha Merkerson & J.C. Chasez
Episode number: 39
Gabrielle Union
Episode number: 40
Isaac's It Girls
Episode number: 41
Jamie Lynn Sigler
Episode number: 42
Gina Gershon
Episode number: 43
Huey Lewis
Episode number: 44
Tony Danza
Episode number: 45
Isaac's Famous Friends
Episode number: 46
Isaac's TV Darlings
Episode number: 47
Isaac's Celebrity Field Trips
Episode number: 48
Keira Knightley
Episode number: 49
Selma Blair
Episode number: 50
Niecy Nash
Episode number: 51
Finola Hughes
Episode number: 52
Madonna
Episode number: 53
Gastineau Girls
Episode number: 54
Lisa Loeb
Episode number: 55